THE EFFECT OF METABOLIC DISORDERS IN WOMEN ON IVF OUTCOMES
Abstract
The authors analyzed the outcomes of in vitro fertilization (IVF) over the past three years. Revealed a decrease in the number of cases of pregnancy after IVF by almost two times. This fact prompted the present study, which aimed to identify possible factors leading to a decrease in the effectiveness of IVF. 94 outpatient cards of patients who entered the program were analyzed. The structure of the causes of infertility, the features of the anamnesis, somatic status, data from an objective and clinical and laboratory examination were studied. It was revealed that the structure of the causes of infertility did not change significantly over a three-year period. The most common reason for referral to IVF was tubal- peritoneal infertility. Most of the women were aged 35-39 years (26%), i.e. they belonged to the late reproductive period. There is an increase in patients of the older age group of 40-45 years. Half of the patients had an increased body mass index: in 30% of patients, body weight was overweight, and 20% had varying degrees of obesity, of which 7% had severe obesity. The most common comorbidity was autoimmune thyroiditis (AIT) with hypothyroidism, with a significant increase in this disease over the course of three years. An increase in the incidence of carbohydrate metabolism disorders was revealed: insulin resistance and type 2 diabetes mellitus (DM 2), a correlation was established between the frequency of diabetes and obesity.
References
Список литературы
ЭКО при гинекологических и эндокринных заболеваниях /под ред. Т. А. Назаренко. – М.: ГЭОТАР-Медиа, 2016. – 176 с
Бесплодный брак: версии и контраверсии / [Радзинский В. Е., Оразов М. Р., Локшин В. Н. и др.] ; под редакцией члена-корреспондента РАН, профессора В. Е. Радзинского. 2-е издание, переработанное и дополненное – Москва: ГЭОТАР-Медиа, 2020. - 432 с
Бесплодие: диагностика, современные методы лечения / Н. М. Подзолкова, Н. Л. Шамугия, Ю. А. Колода, М. Ю. Скворцова. - Москва : ГЭОТАР-Медиа, 2018. - 141 с. : ил., табл.; 19 см. - (Практикующему врачу-гинекологу)
«Российская Ассоциация Репродукции Человека» - Регистр ВРТ. Отчет за 2019 год.– 54 с.
Никонова Л.В., Давыдчик Э.В., Тишковский С.В., Гадомская В.И. Заболевания щитовидной железы и беременность. Часть I. аутоиммунный тиреоидит, гипотиреоз, тиреотоксикоз при беременности: современные принципы диагностики и лечения // Журнал Гродненского государственного медицинского университета. 2016.
Перминова С.Г. Женское бесплодие и нарушение функции щитовидной железы // Бесплодный брак. Современные подходы к диагностике и лечению. Под ред. Г.И. Сухих, Т.А. Назаренко 2 изд. испр. и доп. - М.,: ГЭОТАР-МЕДИА.- 2010. - С 237-272.
Ahmad Jayedi, Sepideh Soltani, Sheida Zeraat-talab Motlagh, et al. Anthropometric and adiposity indicators and risk of type 2 diabetes: systematic review and dose-response meta-analysis of cohort studies. BMJ 2022
References
EKO pri ginekologicheskikh i endokrinnykh zabolevaniyakh /pod red. T. A. Nazarenko. – M.: GEOTAR-Media, 2016. – 176 s
Besplodnyy brak: versii i kontraversii / [Radzinskiy V. E., Orazov M. R., Lokshin V. N. i dr.] ; pod redaktsiey chlena-korrespondenta RAN, professora V. E. Radzinskogo. 2-e izdanie, pererabotannoe i dopolnennoe – Moskva : GEOTAR-Media, 2020. - 432 s
Besplodie: diagnostika, sovremennye metody lecheniya / N. M. Podzolkova, N. L. Shamugiya, Yu. A. Koloda, M. Yu. Skvortsova. - Moskva : GEOTAR-Media, 2018. - 141 s. : il., tabl.; 19 sm. - (Praktikuyushchemu vrachu-ginekologu)
«Rossiyskaya Assotsiatsiya Reproduktsii Cheloveka» - Registr VRT. Otchet za 2019 god.– 54 s.
Nikonova L.V., Davydchik E.V., Tishkovskiy S.V., Gadomskaya V.I. Zabolevaniya shchitovidnoy zhelezy i beremennost’. Chast’ I. autoimmunnyy tireoidit, gipotireoz, tireotoksikoz pri beremennosti: sovremennye printsipy diagnostiki i lecheniya // Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2016.
Perminova S.G. Zhenskoe besplodie i narushenie funktsii shchitovidnoy zhelezy // Besplodnyy brak. Sovremennye podkhody k diagnostike i lecheniyu. Pod red. G.I. Sukhikh, T.A. Nazarenko 2 izd. ispr. i dop. - M.,: GEOTAR-MEDIA.- 2010. - S 237-272.
Ahmad Jayedi, Sepideh Soltani, Sheida Zeraat-talab Motlagh, et al. Anthropometric and adiposity indicators and risk of type 2 diabetes: systematic review and dose-response meta-analysis of cohort studies. BMJ 2022
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