PREVALENCE OF HFE rs1800562 POLYMORPHISM IN NON-ALCOHOLIC FATTY LIVER DISEASE SUSPICIOUS PATIENTS WITH METABOLIC SYNDROME

  • Darya V. Lagutinskaya Research Institute for Medical Problems in the North - Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”; Siberian Federal University https://orcid.org/0000-0003-1295-9262
  • Olga V. Smirnova Research Institute for Medical Problems in the North - Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”; Siberian Federal University https://orcid.org/0000-0003-1295-9262
Keywords: non-alcoholic fatty liver disease, metabolic syndrome, HFE

Abstract

In recent years, metabolic syndrome has assumed epidemic proportions, affecting large populations around the world. rs1800562 mutant polymorphism of the HFE gene is associated with the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma, and its prevalence in the group of patients with metabolic syndrome living in the Krasnoyarsk Territory has practically not been studied.

It was found that the occurrence of mutant genotypes of the rs1800562 gene polymorphism in the control group significantly differed from global data.

Author Biographies

Darya V. Lagutinskaya, Research Institute for Medical Problems in the North - Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”; Siberian Federal University

research laboratory assistant

Olga V. Smirnova, Research Institute for Medical Problems in the North - Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”; Siberian Federal University

MD, PhD

References

Список литературы

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References

Madaleine G., Majumdar A. Metabolic associated fatty liver disease: Addressing a new era in liver transplantation // World Journal of Hepatology. 2020, V. 12, № 12, pp.1168-1181.

Corridani E., et. al. Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with NAFLD // Journal of Hepatology. 2021, V. 75, pp. 506-513.

Ye Q., et. al. Association between the HFE C282Y, H63D Polymorphisms and the Risks of Non Alcoholic Fatty Liver Disease, Liver Cirrhosis and Hepatocellular Carcinoma: An Updated Systematic Review and Meta-Analysis of 5,758 Cases and 14,741 Controls // PloS One. 2016, V. 11, № 9, pp. e0163423.

Smirnova O. V., et. al. Osobennosti kletochnogo i gumoralnogo immuniteta u bolnuh ostrymi nelimfoblastymi i limfoblastnymi leikozami [The peculiarities of cellular and humoral immunity in patients with acute alymphoblastic and acute lymphoblastic leukemia] // Siberian Medical Journal (Irkutsk). 2006. V. 59, № 1, pp. 35-38.

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Published
2022-12-29
How to Cite
Lagutinskaya, D., & Smirnova, O. (2022). PREVALENCE OF HFE rs1800562 POLYMORPHISM IN NON-ALCOHOLIC FATTY LIVER DISEASE SUSPICIOUS PATIENTS WITH METABOLIC SYNDROME. International Journal of Advanced Studies in Medicine and Biomedical Sciences, (2), 15-21. Retrieved from http://sic-publ.press/index.php/mbs/article/view/4
Section
Original Articles