PHAGOCYTIC ACTIVITY OF CLASSICAL AND NON-CLASSICAL MONOCYTES IN ATHEROSCLEROTIC LESION OF THE CORONARY ARTERIES
Abstract
The main cause of coronary artery disease is atherosclerosis, which is a multifactorial degenerative disease of the coronary arteries of large and medium size, which includes impaired lipid metabolism, abnormal platelet function and increased phagocytic activity of neutrophilic granulocytes and monocytes. The phenotypic composition of monocytes in patients with atherosclerotic lesions of the coronary arteries was studied. The prevalence of the population of classical monocytes in the peripheral blood was shown against the background of a pronounced decrease in transient and pro-inflammatory monocytes. The functional activity of different phenotypes of monocytes in patients with atherosclerotic lesions of the coronary arteries was studied. An increase in the number of classical and pro-inflammatory monocytes actively involved in the process of phagocytosis was shown.
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